Vitamin D Receptor Activator and Dietary Sodium Restriction to Reduce Residual Urinary Albumin Excretion in Chronic Kidney
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Vitamin D receptor activator and dietary sodium restriction to reduce residual urinary albumin excretion in chronic kidney disease (ViRTUE study): rationale and study protocol.
UNLABELLED Optimal albuminuria reduction is considered essential to halting chronic kidney disease (CKD) progression. Both vitamin D receptor activator (VDRA) treatment and dietary sodium restriction potentiate the efficacy of renin-angiotensin-aldosterone-system (RAAS) blockade to reduce albuminuria. The ViRTUE study addresses whether a VDRA in combination with dietary sodium restriction provi...
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Reduction of residual albuminuria during single-agent renin-angiotensin-aldosterone blockade is accompanied by improved cardiorenal outcomes in CKD. We studied the individual and combined effects of the vitamin D receptor activator paricalcitol (PARI) and dietary sodium restriction on residual albuminuria in CKD. In a multicenter, randomized, placebo (PLAC)-controlled, crossover trial, 45 patie...
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BACKGROUND Vitamin D receptor activators reduce albuminuria, and may improve survival in chronic kidney disease (CKD). Animal studies suggest that these pleiotropic effects of vitamin D may be mediated by suppression of renin. However, randomized trials in humans have yet to establish this relationship. METHODS In a randomized, placebo-controlled, double-blinded crossover study, the effect of...
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Influence of aldosterone on sodium, water and potassium metabolism in chronic renal disease. To evaluate the physiological importance of aldosterone in chronic renal disease, ii studies were performed in nine patients with renal impairment of varying etiology and severity during periods of normal and low sodium intake. Decreased sodium excretion during sodium restriction was accompanied by incr...
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تاریخ انتشار 2018